Joint pain can be caused by injury affecting any of the ligaments, bursae, or tendons surrounding the joint. Injury can also affect the ligaments, cartilage, and bones within the joint. Pain is also a feature of joint inflammation ( arthritis , such as rheumatoid arthritis and osteoarthritis ) and infection, and extremely rarely it can be a cause of cancer of the joint. Pain within the joint is a common cause of shoulder pain , ankle pain , and knee pain . Joint pain is also referred to as arthralgia . The sexually transmitted diseases ( STDs ) chlamydia and gonorrhea can lead to joint pain.
For moderate-to-severe joint pain with swelling, an over-the-counter or prescription nonsteroidal anti-inflammatory drug (NSAID) such as aspirin , ibuprofen ( Advil , Motrin ), or naproxen sodium ( Aleve ), can provide relief. A newer generation of NSAIDs known as Cox-2 inhibitors (celcoxib) is also good for pain relief, but all except one of these drugs ( Celebrex ) have been removed from the market because of an increased risk of heart attack , stroke , and other cardiovascular events. NSAIDs also can have side effects, potentially increasing your risk for gastrointestinal bleeding.
Three hundred and seventeen patients with 328 fractures were randomized to receive vitamin C, and ninety-nine patients with ninety-nine fractures were randomized to receive a placebo. The prevalence of complex regional pain syndrome was % (eight of 328) in the vitamin C group and % (ten of ninety-nine) in the placebo group (p=); all of the affected patients were elderly women. Analysis of the different doses of vitamin C showed that the prevalence of complex regional pain syndrome was % (four of ninety-six) in the 200-mg group (relative risk, ; 95% confidence interval, to ), % (two of 114) in the 500-mg group (relative risk, ; 95% confidence interval, to ), and % (two of 118) in the 1500-mg group (relative risk, ; 95% confidence interval, to ). Early cast-related complaints predicted the development of complex regional pain syndrome (relative risk, ; 95% confidence interval, to ).