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Almost half of all European patent applications came from the EPO member states, followed by the US, Japan, China and South Korea. Applications from Europe were on a par with last year, with marked differences among individual countries. Europe’s growth champions were Belgium and Italy. More modest rises came from Austria, Spain, Switzerland and the UK. Demand from Europe’s biggest patent applicant, Germany, was stable, while France, the Netherlands and many of the Nordic countries filed fewer applications. Overall, China (and to a lesser extent South Korea) was the main driver of growth in applications at the EPO. Applications from the US dropped considerably (although this was only a correction after the one-off jump in 2015 resulting from a change in US patent law), while Japanese companies filed slightly fewer applications.
The exact dosing instructions for nitric oxide supplement is not known. However, most supplements contain an average dose of grams of L-arginine and L-citrulline. We suggest you follow a process known as tolerance mapping to understand just how much nitric acid is required for your body. The process is simple. All you have to do is start with a small dose in Week 1. During the first week, make sure you note down the benefits and side effects that you are feeling. Once your body has adjusted to the lowest dose possible, you can then increase the dosing until you start feeling beneficial effects. Gradually, your body starts adjusting to the supplement and you will hit your optimal dose. However, the temporary recommendations for the supplement that you can take 2000mg-6000mg per day for optimum effects. Please note that overdosing is possible as dose variations can happen due to physiological differences. In case you notice diarrhea, vomiting, weakness, and nausea, stop the supplement immediately and consult your personal physician. Please note that liquids are absorbed much faster than solids and dosages for liquids will be lower than that of solid preparations.