As you are aware, the supplement industry is a massive one and big money is involved. Year after year existing companies are searching for newer and bigger products and the line of natural steroids is ever expanding. However, you may have noticed quite often many of these products are pulled from the shelf almost as fast as they arrived. Generally there are two reasons for this occurrence; the first is perhaps the most common; as a product hits the shelves, eventually some of the ingredients are deemed part of a banned substance list by governing officials. The second most common fate of many natural steroids is a bit simpler; manufactures end up putting already banned ingredients into the supplement; actual synthetic steroidal hormones added into the product is not as unheard of as you may think. Even so, there are products that survive and each year new ones hit the shelves. These newly developed natural steroids will continue to hit the shelves as long as performance is rewarded and as long as the everyday guy desires a physique he can be proud of.
Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile .  The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception .  In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone.  The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field.  The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.