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AIs are categorized into two types: 1) non-steroidal inhibitors such as Arimidex ( anastrozole ) and Femara ( letrozole ) which inhibit the enzyme by reversible competition and; 2) irreversible steroidal inhibitors such as Aromasin (exemestrane) which form a permanent bond with the aromatase enzyme complex. Lentaron is classified in the second group as a selective irreversible steroidal aromatase inhibitor. Derived from androstenedione (the same except for the addition of a 4-hydroxyl group), formestane forms an irreversible bond with the aromatase enzyme which permanently deactivates it. It takes several days (following formestane discontinuation) for aromatase to become active again. These types of drugs are often referred to as suicidal aromatase inhibitors because the drugs seemingly sacrifice themselves (their structural independence) in the process of blocking estrogen.