Kisspeptin plays a role in tumor suppression. In a study where malignant tumor cells were injected into a model system , the system was then tested for genes involved in the injected chromosome 6. KISS1 was discovered to be the only gene expressed in non-metastatic cells and absent in metastatic, metastatic meaning the ability for cancer to spread to unconnected areas. This suggested that there Kisspeptin is an essential regulation factor in whether or not a cell will be metastatic or not. Additional experimentation identified CRSP3 as the exact gene responsible for KISS1 regulation within chromosome 6. In clinical evidence studies, KISS1 and Kisspeptin were found in primary, metastatic tumors, and growing tumors showing decreased levels of KISS1 and Kisspeptin.  In conclusion, kisspeptin plays a large role in tumor suppression . When it is active in cells the tumor stays consolidated and does not spread or grow.
In adults with GHD, the FDA-approved labeling states that the starting dosage of GH should be very low ( to mg/day). The product labeling further states that this dose should be increased gradually on the basis of clinical and biochemical responses assessed at monthly intervals. The biochemical marker generally relied upon for GH is the IGF-I level in serum. Values of IGF-I should be maintained in the normal age- and sex-adjusted range. The literature indicates that the dose may be increased, on the basis of individual patient requirements, to a maximum of mg daily in patients younger than 35 years of age, and to a maximum of mg daily in patients older than 35 years of age. Of note, this dose is substantially less than GH replacement doses in children and adolescents, in whom the dose is based on weight.
Shawn Wells , a diet and nutrition expert and chief scientific officer at BioTRUST Nutrition, says, “Ninety percent of the time, proprietary blends are about listing things for marketing purposes and saving a lot of money.” He explained that “people think they are getting all these listed ingredients, but out of a total of 4,000 mg of a supplement, 3,999 mg could be, say, creatine, and only 1 mg could be BCAAS, which is what you really want. There’s no way to know.” He added that proprietary blends can also pose a danger when they contain certain ingredients, say, stimulants like caffeine or synephrine, which can be unsafe in larger doses.