Studies also suggest that an over-the-counter supplement called glucosamine sulfate is safe and may help people with osteoarthritis in the knees. A study published in 2001 described improvement over three years for patients taking 1,500 milligrams of glucosamine a day compared with a placebo (an inactive pill). A newer study in 2006 found that glucosamine seems to work better when combined with chondroitin for moderate to severe osteoarthritis. However, there is no compelling evidence that joint deterioration can be slowed or stopped by treatment with glucosamine. The issue continues to be studied. Over-the-counter creams containing capsaicin applied to the skin over painful joints also may help.
In a landmark paper, Liggins and Howie showed that a single course of antenatal corticosteroid therapy administered to women at risk for preterm delivery (PTD) reduced the incidence and severity of respiratory distress syndrome (RDS) and mortality in offspring [ 1 ]. Over two dozen randomized trials have confirmed these findings [ 2 ]. Subsequent trials have also shown that antenatal corticosteroid therapy improves circulatory stability in preterm neonates, resulting in lower rates of intraventricular hemorrhage (IVH) and necrotizing enterocolitis compared with unexposed preterm neonates.